FAQ: Intracytoplasmic Sperm Injection
- What is ICSI?
- Who should consider ICSI?
- Who should consider split ICSI?
- How successful is ICSI?
- What are the risks associated with ICSI?
- Will all of our eggs be injected?
- ICSI和非ICSI胚胎在胚胎质量或妊娠率上有差异吗?
What is ICSI?
Intracytoplasmic sperm injection, or ICSI, involves injecting a single live sperm directly into the center of a human egg. 这项技术的发展是为了帮助患有严重糖尿病的夫妇受精 male factor infertility 或者在之前的体外受精(IVF)尝试中失败的夫妇. 这一过程克服了许多受精障碍,使没有希望成功怀孕的夫妇获得受精胚胎.
这一过程需要女性伴侣用生育药物刺激卵巢,使几个成熟的卵子发育. These eggs are then aspirated through the vagina using vaginal ultrasound, and incubated under precise conditions in the embryology laboratory. 精液样本是通过离心或通过特殊介质旋转精子细胞制备的. This separates live sperm from debris and most of the dead sperm. 然后,胚胎学家用玻璃针取出单个活精子,直接注射到卵子中.
ICSI was first used at UCSF in 1994, 1995年2月,我们第一次在ICSI的帮助下成功分娩. 加州大学旧金山分校是旧金山湾区第一个用这种方法实现怀孕和分娩的项目.
Who should consider ICSI?
在精液分析异常的男性因素不育的情况下,ICSI被认为是绝对必要的. In the Bay Area, however, about 75 percent of all IVF cases are now ICSI. 除男性因素不育外,患者选择接受ICSI的原因包括:
- Previous poor fertilization with IVF
- Variable sperm counts
- Unexplained infertility
许多患者选择接受ICSI手术,以最大限度地提高他们的成功,即使程序没有明确指出.
If you have been told that there are abnormalities with any sperm test results, you should give serious consideration to ICSI. If the male partner has had a vasectomy reversal, 无论精子质量如何,我们也推荐ICSI,因为精子抗体的存在可能会影响受精.
如果没有男性因素不育的证据,进行ICSI的决定是特别困难的. 有些夫妇选择ICSI是因为他们想要尽一切可能最大化受精. However, 重要的是要明白,对于许多精子参数正常的夫妇, 在体外受精过程中,不使用ICSI的标准授精可以达到最大的受精.
Who should consider split ICSI?
对于有兴趣了解自己受精能力的夫妇,我们提供分裂ICSI. 这种选择包括对大多数成熟卵子进行ICSI,并将剩余的卵子与精子孵育. In effect, 分裂ICSI可以提供一个安全网,防止失败的受精与标准的授精.
The fee charged for split ICSI is the same as ICSI. One requirement for split ICSI is a minimum number of mature eggs. 我们必须能够在取卵当天识别出至少8个成熟的卵子,以便进行分裂ICSI. If this requirement is not met, we will inject all of your mature eggs.
How successful is ICSI?
Through the ICSI procedure, 许多有男性因素不育问题的夫妇在加州大学旧金山分校成功怀孕. 目前已经实现了70%到80%的受精率——相当于正常精子的受精率, 怀孕率与没有男性因素不育的夫妇进行体外受精的情况相当.
ICSI成功的最重要指标似乎是ICSI手术的受精率. 加州大学旧金山分校试管婴儿实验室的受精率非常高,目前为80%至85%. That is to say, on average, eight out of every 10 eggs will fertilize normally.
What are the risks associated with ICSI?
There are several risks. First, during the ICSI procedure, 少数卵子——通常少于5%——会因为针头的插入而受损. Second, 生下X染色体或Y染色体异常的婴儿的总体风险为0.8 percent, or eight per 1000, which is four times the average seen with spontaneous conception. At present, we do not know the reason for this increased risk.
重要的是要了解以下问题可能与性染色体异常有关:
- Increased risk of miscarriage
- Heart problems for affected infants that may require surgery
- Increased risk of behavior or learning disabilities
- Increased risk of infertility in your children during their adulthood
有染色体异常的风险,如唐氏综合症,不会随着ICSI而增加,但随着母亲年龄的增加而增加.
一些研究已经解决了ICSI出生的儿童发育迟缓的问题. However, there is no conclusive evidence that this is the case.
Will all of our eggs be injected?
如果您决定进行ICSI,我们将尽一切努力注入尽可能多的卵子. 重要的是你要明白,只有成熟的卵子才能注射精子. Our IVF laboratory can easily tell if an egg is mature or immature. 虽然未成熟的卵子与精子一起孵化,但受精的可能性非常低. 平均而言,我们能够将回收卵子的75%到80%注射进去.
ICSI和非ICSI胚胎在胚胎质量或妊娠率上有差异吗?
与非ICSI胚胎相比,ICSI胚胎获得的整体胚胎质量似乎没有差异. 同样,ICSI胚胎和非ICSI胚胎之间的妊娠率也没有差异. Although unproven, 许多不孕症专家认为,ICSI可以从一定数量的卵子中增加胚胎产量, which has contributed to the increase in ICSI procedures.
UCSF Health medical specialists have reviewed this information. 它仅用于教育目的,并不打算取代您的十大赌博平台排行榜或其他医疗保健提供者的建议. 我们鼓励您与您的供应商讨论您可能遇到的任何问题或疑虑.