Glucose-6-phosphate dehydrogenase test

定义

Glucose-6-phosphate dehydrogenase (G6PD) is a protein that helps red blood cells work properly. The G6PD test looks at the amount (activity) of this substance in red blood cells.

Alternative Names

RBC G6PD test; G6PD screen

How the Test is Performed

A 血液样本 是必要的.

How to Prepare for the Test

No special preparation is usually necessary.

How the Test will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

Why the Test is Performed

Your health care provider may recommend this test if you have signs of G6PD缺乏症. This means you do not have enough G6PD activity.

Too little G6PD activity leads to the destruction of red blood cells. This process is called 溶血. When this process is actively occurring, it is called a hemolytic episode.

Hemolytic episodes can be triggered by infections, certain foods (such as fava beans), and certain medicines, 包括:

• Drugs used to reduce fever
• 呋喃妥英
• 非那西汀
• 伯氨喹
• 磺胺类药
• Thiazide diuretics
• 甲苯磺丁脲
• 奎尼丁

正常的结果

Normal values vary and depend upon the laboratory used. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

Abnormal results mean you have a G6PD缺乏症. 这会导致 hemolytic anemia in certain conditions.

风险

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a 血液样本 from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

• Excessive bleeding
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• Hematoma (blood buildup under the skin)
• Infection (a slight risk any time the skin is broken)

参考文献

Chernecky CC, Berger BJ. Glucose-6-phosphate dehydrogenase (G6PD, G-6-PD), quantitative - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6日艾德. St Louis, MO: Elsevier Saunders; 2013:594-595.

加拉格尔PG. Hemolytic anemias: red blood cell membrane and metabolic defects. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26日艾德. Philadelphia, PA: Elsevier; 2020:chap152.

Kaplan M, Wong RJ, Burgis JC, Sibley BE, Stevenson DK. Neonatal jaundice and liver diseases. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin's Neonatal-Perinatal Medicine. 11日艾德. Philadelphia, PA: Elsevier; 2020:chap 91.